Personalized Treatment of Breast Cancer by Masakazu Toi Eric Winer John Benson & Suzanne Klimberg

Author:Masakazu Toi, Eric Winer, John Benson & Suzanne Klimberg
Language: eng
Format: epub
Publisher: Springer Japan, Tokyo

12.10 Ongoing Trials Investigating the Role of RT After NAC

There are two ongoing randomized NAC trials that are open for accrual in the USA. The NSABP B-51/RTOG 1304 (NRG 9353) trial is enrolling patients with clinical stage II–III breast cancer (T1-3N1M0) with biopsy-proven axillary nodal disease (Fig. 12.1). Patients receive NAC with anti-Her2-targeted therapy if Her2+. Patients who are pathologically node negative at surgery (by axillary dissection or sentinel lymph node biopsy) are randomized to breast RT alone (lumpectomy) or no RT (mastectomy) vs. breast RT with regional nodal irradiation or PMRT with regional nodal irradiation. This study aims to evaluate the benefits of adjuvant radiation therapy, including regional nodal irradiation, in patients who are initially node positive and become node negative after NAC [29].

Fig. 12.1NSABP B-51/RTOG 1304 (NRG 9353) schema. Abbreviations: NAC neoadjuvant chemotherapy, ALND axillary lymph node dissection, SLNB sentinel lymph node biopsy, WBI whole-breast irradiation, RNI regional nodal irradiation

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